DNAging Research


Geriomics Team


Douglas P. Kiel, M.D., M.P.H.

  • Director Musculoskeletal Research Center and Senior Scientist, Marcus Institute for Aging Research

  • Associate Member, Broad Institute of MIT & Harvard

  • Professor of Medicine, Harvard Medical School

Dr. Kiel's research focuses on the epidemiology of osteoporosis and related fractures, including lifestyle factors, biomarkers, and genetic factors.  He is also interested in sarcopenia and its consequences, including falls and disability.  He also has conducted multiple clinical trials targeting the musculoskeletal system.  He leads the Framingham Osteoporosis Study, and serves in leadership roles for many organizations including the NIH, American Society for Bone and Mineral Research, National Osteoporosis Foundation, and the Joint Commission.


David Karasik, Ph.D.

  • Associate Scientist, Marcus Institute for Aging Research

David Karasik's overall research focus is in the area of interpersonal variability of aging, ranging from morphological changes in ossified tissues to the genetics of age-related conditions, such as osteoporosis, sarcopenia (muscle wasting), and menopause. His special interest is in identifying the pleiotropic genetic factors governing multiple aging-related traits.

Dr. Karasik has many years of teaching Human Gross Anatomy. Currently, he is serving as a Head of the Anatomy Program in the newly formed Faculty of Medicine, Bar Ilan University, Israel.


Yi-Hsiang (Sean) Hsu, Sc.D.

  • Associate Director Geriomics Program, Marcus Institute for Aging Research

  • Program for Quantitative Genomics

  • Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health.

  • Assistant Professor of Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School

  • Associate Member, Broad Institute of MIT & Harvard

Dr. Hsu’s research is focused on (1) the genetic contribution to common aging relevant disorders using population-based next generation, whole genome sequencing, exome-sequencing and GWAS approaches; (2) statistical method development on multiple-phenotype association analyses; and (3) identifying biomarkers of osteoporosis using metabolomics.



Michelle Yau, Ph.D.

  • Post-Doctoral Research Fellow, Marcus Institute for Aging Research

  • Research Fellow in Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School

  • Affiliate Member, Broad Institute of MIT & Harvard

Dr. Michelle Yau is a T32-funded post-doctoral research fellow in the Musculoskeletal Research Group at the Marcus Institute for Aging Research, Hebrew SeniorLife.  Her research focuses on identifying the genetic/genomic contributions to common age-associated conditions such as osteoarthritis (OA), osteoporosis, and intervertebral disc degeneration.  

Dr. Yau’s current research aims to identify the genetic components of OA and its relationship to bone.  She is particularly interested in bone marrow lesions as an endophenotype for OA.  Bone marrow lesions are a specific MRI-feature that may reflect areas of damage in the subchondral bone and represent some of the earliest changes underlying OA pathophysiology.  To further understand the genetic contribution to bone marrow lesions, she is conducting a large-scale genome-wide association meta-analysis study of bone marrow lesions and a RNA-sequencing study of OA bone samples.  Dr. Yau is also involved in other studies to identify clinical and epigenetic factors related to OA, genetic components of other musculoskeletal endophenotypes such as finger length and bone shape, and African ancestry-specific genetic contributions to bone mineral density.

Dr. Yau received a BS in Biochemistry from the University of Maryland, MPH in Epidemiology from The George Washington University, and PhD in Human Genetics from the University of Maryland.  She is an active member of the Association of Rheumatology Health Professionals (ARHP) Research Methodology Committee and Osteoarthritis Research Society International (OARSI) Young Investigator Committee.


Fredrick Kinyua

  • Programmer Analyst II

Dr. Kinyua received his undergraduate degree in biomedical science/technology, then completed a Masters degree in bioinformatics.  His PhD was obtained in Bioscience.  Before coming to the Geriomics Program, Dr. Kinyua worked on building computational pipelines for “omic” data and studied gene-environment interactions.  He currently serves as a bioinformatician and genetic analyst for the Geriomics Program